Arline kaplan biography of donald
Arlene Kaplan Daniels, whose colorful, witty, and generous presence enlivened the field of sociology, died in her sleep on January
$ Arlene Kaplan Daniels.!
The Race to Patent Bio-tests for Schizophrenia and Depression
The articles by Arline Kaplan and Hagop Asiskal, MD, in the November 2011 issue of Psychiatric Times1,2 highlight the race to patent bio-tests for schizophrenia and depression.
Alas, this drive is destined to fail for the same reason that earlier biotests failed-the heterogeneity of the populations for these disorders as defined by the DSM criteria. The failure of the STAR*D, STEP-BD, and CATIE studies to find assured efficacy for the treatments in the trials is sufficient evidence to question the DSM criteria.
Dr Akiskal notes that “the dexamethasone suppression test [DST] was considered to have acceptable sensitivity and specificity for melancholia, rather than broadly defined depression.”2 But it was the view of key opinion leaders of an NIMH committee in 1982 and the 1986 Glassman APA Commission that the failure of the DST to define “major depression” doomed it for rejection in the clinic.
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